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A case of double cancer involving oral malignant melanoma and gastrointestinal stromal tumor (GIST).

Nagai K, Matsumura Y, Nomura J, Inui M, Tagawa T

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan. knagai@mocha.ocn.ne.jp

We report a very rare case of double cancer involving palatal malignant melanoma and gastrointestinal stromal tumor (GIST), a rare tumor of the gastrointestinal tract originating from a primitive mesenchymal cell. After chemotherapy, radiation therapy, and treatment with interferon and OK-432, the GIST was resected and the melanoma disappeared. The patient has had no evidence of recurrent tumor, and the patient's clinical course has been uneventful for 1 year. This is probably the first report of synchronous double cancer involving oral malignant melanoma and GIST.

Published 2 March 2005 in Int J Oral Maxillofac Surg, 34(3): 328-30.
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