Bone Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Bone Cancer, including details on symptoms, types, treatment.

Extracorporeal irradiated autogenous osteochondral graft: a histological study.

Hatano H, Ogose A, Hotta T, Endo N, Umezu H, Morita T

Department of Orthopaedic Surgery, Niigata Cancer Center Hospital, 2-15-3, Kawagishi-Cho, Niigata City 951-8510, Japan. hatanoh@niigata-cc.jp

We examined osteochondral autografts, obtained at a mean of 19.5 months (3 to 48) following extracorporeal irradiation and re-implantation to replace bone defects after removal of tumours. The specimens were obtained from six patients (mean age 13.3 years (10 to 18)) and consisted of articular cartilage (five), subchondral bone (five), external callus (one) and tendon (one). The tumour cells in the grafts were eradicated by a single radiation dose of 60 Gy. In three cartilage specimens, viable chondrocytes were detected. The survival of chondrocytes was confirmed with S-100 protein staining. Three specimens from the subchondral region and a tendon displayed features of regeneration. Callus was seen at the junction between host and irradiated bone.

Published 23 June 2005 in J Bone Joint Surg Br, 87(7): 1006-11.
Full-text of this article is available online (may require subscription).

© 2004-2008 Bone Cancer Research Today. All Rights Reserved.