Bone Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Bone Cancer, including details on symptoms, types, treatment.

Successful hormone treatment of orbital leiomyoma.

Wrede J, Helmke B, Hartmann M, Voelcker HE, Dithmar S

Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.

PURPOSE: To describe the successful hormone treatment of noncircumscribed orbital leiomyoma. DESIGN: Case report. PARTICIPANT: A 66-year-old woman with histologically proven orbital leiomyoma. METHODS: Because surgical excision of the tumor was impossible, therapy with the gonadotropin-releasing hormone (GnRH) analog goserelin was performed. RESULTS: Hormone treatment was well tolerated and no side effects were noted. The tumor regressed significantly during treatment. No recurrence occurred during a 5-year follow-up period. CONCLUSIONS: This report describes for the first time successful hormone treatment of a noncircumscribed orbital leiomyoma. Goserelin may have an antiproliferative effect on leiomyoma cells via membrane receptors for GnRH.

Published 4 July 2005 in Ophthalmology, 112(7): 1316-8.
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