Bone Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Bone Cancer, including details on symptoms, types, treatment.

CGH evaluation of two de novo synchronous tumors in a child with a germline p53 mutation.

Roque L, Lacerda A, Rodrigues R, Almeida O, Salgueiro J, Pinto C

Cytogenetic Laboratory, CIPM, Portuguese Cancer Institute, Lisbon, Portugal. lroque@ipolisboa.min-saude.pt

We report the case of a child who developed two de novo synchronous tumors: an osteosarcoma and an embryonal rhabdomyosarcoma. The patient was determined to be a de novo carrier of a P53 germline mutation. Comparative genomic hybridization (CGH) analysis revealed that each of the neoplasms was characterized by a specific set of chromosomal imbalances and high-level amplification (HLA) regions. Our CGH findings provide evidence that cancer development is a cellular/organ specific event.

Published 10 October 2006 in Pediatr Blood Cancer, 47(7): 949-54.
Full-text of this article is available online (may require subscription).

© 2004-2008 Bone Cancer Research Today. All Rights Reserved.