Bone Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Bone Cancer, including details on symptoms, types, treatment.

Oral leiomyosarcomas: report of two cases with immunohistochemical profile.

Rodini CO, Pontes FS, Pontes HA, Santos PS, Magalhães MG, Pinto DS

Department of Stomatology (Oral Pathology), Dental School, University of São Paulo, São Paulo, Brazil. carodini@usp.br

Leiomyosarcoma of the oral cavity is a very rare tumor associated with aggressive clinical behavior and low survival. In this paper, we report 2 cases of leiomyosarcoma, affecting the gingival mucosa of a 54-year-old female and the maxillary bone of a 63-year-old male. Histologically, the tumors were composed of variably oriented fascicles of spindle-shaped cells with cigar-shaped nuclei and eosinophilic cytoplasm. The lesions were treated by surgical resection. Immunoreactivity to anti-vimentin, anti-smooth muscle actin, anti-desmin, anti-laminin, and anti-muscle-specific actin antibodies were found; conversely, the tumor cells were negative for anti-S100 and AE1/AE3 proteins. This report emphasizes the role of immunohistochemical study for correct diagnosis of leiomyosarcoma.

Published 1 October 2007 in Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 104(4): e50-5.
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