Bone Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Bone Cancer, including details on symptoms, types, treatment.

Diffuse uterine leiomyomatosis with uterine rupture and benign metastatic lesions of the bone.

Thomas EO, Gordon J, Smith-Thomas S, Cramer SF

Department of Obstetrics and Gynecology, Rochester General Hospital, Rochester, New York 14621, USA. ethomas3@rochester.rr.com

BACKGROUND: We report a case of diffuse uterine leiomyomatosis in pregnancy complicated by uterine rupture and dissemination to the bone. CASE: A 35-year-old nulliparous woman with a history of uterine leiomyoma presented at term with fetal demise. Failed induction of labor and hemodynamic instability due to uterine rupture resulted in a cesarean hysterectomy. A free-air series performed postoperatively to confirm paralytic ileus revealed multiple lytic bone lesions. The diagnosis of diffuse uterine leiomyomatosis with metastasis was made on histology of the resected uterus and fine-needle aspiration biopsy of the bone. She was managed conservatively, and the lesions are now regressing. CONCLUSION: Diffuse uterine leiomyomatosis should be considered in pregnant women with a history of uterine fibroids and peripartum hemorrhage.

Published 1 February 2007 in Obstet Gynecol, 109(2): 528-30.
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