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Multiple complications due to osteoradionecrosis in a patient with thromboangiitis obliterans.

Barkhuysen R, Janssens GO, de Wilde PC, Merkx MA

Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

A case is presented of a patient with thromboangiitis obliterans (TAO) who developed severe necrosis of the intraoral soft tissues and maxillary and mandibular bone after radiotherapy for a cT2N0M0 squamous cell carcinoma of the soft palate. Multiple surgical procedures including partial resection of the mandible and maxilla and reconstruction of intraoral and extraoral defects with a pectoralis major myocutaneous flap and anterolateral thigh flap were performed with partial success. Although a causal relationship between TAO and the described complications cannot be verified, close monitoring of patients with TAO who are being treated with radiotherapy is advised.

Published 19 June 2007 in Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 104(1): e34-7.
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